Jan Vietor

Department für Pharmazie - Zentrum für Pharmaforschung - Ludwig-Maximilians-Universität München Butenandtstraße 7 D-81377 München Zi.Nr.: C1.050B Tel.: +49 (0)89 2180 77928 Fax.: +49 (0)89 2180 77247 Mail: Jan.Vietor@cup.uni-muenchen.de

Research Interest

In the context of neurodegeneration and neuroprotection I am focusing on the nuclear receptor related-1 (Nurr1) as biological target. I am studying the medicinal chemistry of the nuclear receptor by developing small molecule ligands as tool compounds. Performing organic synthesis as well as assessing the synthesized compounds with different in‑vitro methods, I try to examine structure activity relationships in order to obtain potent, efficient and selective Nurr1 agonists.

Publications

Sai, M.; Vietor, J.; Kornmayer, M.; Egner, M.; López-García, U.; Höfner, G.; Pabel, J.; Marschner, J.; Wein, T.; Merk, D. Structure-Guided Design of Nurr1 Agonists Derived from the Natural Ligand Dihydroxyindole. J. Med. Chem., 2023, DOI 

Vietor, J.; Gege, C.; Stiller, T.; Busch, R.; Schallmayer, E.; Kohlhof, H.; Höfner, G.; Pabel, J.; Marschner, J.; Merk, D. Development of a Potent Nurr1 Agonist Tool for In Vivo Applications. J. Med. Chem., 2023, 66, 6391–6402 DOI

Helmstädter, M.; Vietor, J.; Sommer, J.; Schierle, S.; Willems, S.; Kaiser, A.; Schmidt, J.; Merk, D. A new FXR ligand chemotype with agonist/antagonist switch. ACS Med. Chem. Lett., 2021, 12, 267–274 DOI