Dr. Julian Marschner

Department für Pharmazie - Zentrum für Pharmaforschung - Ludwig-Maximilians-Universität München Butenandtstraße 7 D-81377 München Zi.Nr.: C1.063 Tel.: +49 (0)89 2180 77242 Fax.: +49 (0)89 2180 77247 Mail: Julian.Marschner@cup.lmu.de

Publications 

Sai, M.; Vietor, J.; Kornmayer, M.; Egner, M.; López-García, U.; Höfner, G.; Pabel, J.; Marschner, J.; Wein, T.; Merk, D. Structure-Guided Design of Nurr1 Agonists Derived from the Natural Ligand Dihydroxyindole. J. Med. Chem., 2023,  DOI

Zaienne, D.; Isigkeit, L.; Marschner, J.; Duensing-Kropp, S.; Höfner, G.; Merk, D. Structural Modification of the Natural Product Valerenic Acid Tunes RXR Homodimer Agonism. ChemMedChem, 2023, 18, e202300404 DOI  

Arifi, S.; Marschner, J.; Pollinger, J.; Isigkeit, L.; Heitel, P.; Kaiser, A.; Obeser, L.; Höfner, G.; Proschak, E.; Knapp, S.; Chaikuad, A.; Heering, J.; Merk, D. Targeting the Alternative Vitamin E Metabolite Binding Site Enables Noncanonical PPARγ Modulation. J. Am. Chem. Soc., 2023, DOI

Ballarotto, M.; Willems, S.; Stiller, T.; Nawa, F.; Marschner, J.; Grisoni, F.; Merk, D. De Novo Design of Nurr1 Agonists via Fragment-Augmented Generative Deep Learning in Low-Data Regime. J. Med. Chem., 2023, 66, DOI

Vietor, J.; Gege, C.; Stiller, T.; Busch, R.; Schallmayer, E.; Kohlhof, H.; Höfner, G.; Pabel, J.; Marschner, J.; Merk, D. Development of a Potent Nurr1 Agonist Tool for In Vivo Applications. J. Med. Chem., 2023, 66, 6391–6402. DOI

Adouvi, G.; Isigkeit, L.; Lopez, Ú; Marschner, J.; Schubert-Zsilavecz, M.; Merk, D. Rational design of a new RXR agonist scaffold enabling single-subtype preference for RXRα, RXRβ and RXRγ. J. Med. Chem., 2023, 66, 333–344. DOI

Arifi, S.; Zaienne, D.; Heering, J.; Wein, T.; Zhubi, R.; Chaikuad, A.; Knapp, S.; Marschner, J.; Merk, D. Fragment-based discovery of orphan nuclear receptor Nur77/NGFI-B ligands. Bioorg. Chem., 2022, 106164. DOI

Helmstädter, M.; Schierle, S.; Isigkeit, L.; Proschak, E.; Marschner, J.; Merk, D. Activity screening of fatty acid mimetic drugs identified nuclear receptor agonists. Int. J. Mol. Sci., 2022, 23, 10070. DOI

Zaienne, D.; Arifi, S.; Marschner, J.; Heering, J.; Merk, D. Druggability evaluation of the neuron derived orphan receptor (NOR-1) reveals inverse NOR-1 agonists. ChemMedChem, 2022, 17, e202200259. DOI

Willems, S.; Marschner, J.; Kilu, W.; Faudone, G.; Busch, R.; Duensing-Kropp, S.; Heering, J.; Merk, D. Nurr1 modulation mediates neuroprotective effects of statins. Adv. Sci., 2022, 9(18), 2104640. DOI