Department für Pharmazie Zi.Nr.: C1.053 |
The role of nuclear receptors in neurodegenerative diseases evokes interest in the development of potent ligands as tool compounds to study nuclear receptor activity. In this regard, nuclear receptor related 1 (Nurr1) is a target of emerging interest. Besides its activities as monomer and homodimer, Nurr1 can also be active as heterodimer with retinoid X receptors (RXR). Thus, my research focuses on exploring the structure-activity relationship towards dual Nurr1/RXR agonists by organic synthesis as well as in vitro evaluation of compounds.
Menke, J.-M.; Scholz, K.; Trapp, O. Synthesis of Stereochemically Flexible Cyclic Biphenylphosphinite Ligands: Control of the Dynamics and Selectivity. Helv. Chim. Acta, 2021, 104, e2100139 DOI