Tanja Stiller

 

Research Interest

Nuclear receptors are a family of proteins that function as ligand-activated transcription factors and regulate gene expression in a ligand binding-dependent manner. I focus on a master regulator of neurogenesis, the Orphan Nuclear Receptor Tailless Homologue (TLX). Based on library projects, synthesis of new ligands and investigation of biological activity by in vitro methods, I am trying to find potent agonists for TLX.

Publications

Lang, A.; Stiller, T.; Ildefeld, N.; Heitel, P.; Isigkeit, L.; Proschak, E.; Heering, J.; Schubert-Zsilavecz, M.; Merk, D. Fatty Acid Mimetic Fragments as Liver Receptor Homolog-1 Modulators. ACS Pharmacol. Transl. Sci., 2025, DOI

Stiller, T.; Merk, D. Exploring Fatty Acid Mimetics as NR4A Ligands. J. Med. Chem., 2023, 66, 15362–15369. DOI

Ballarotto, M.; Willems, S.; Stiller, T.; Nawa, F.; Marschner, J.; Grisoni, F.; Merk, D. De Novo Design of Nurr1 Agonists via Fragment-Augmented Generative Deep Learning in Low-Data Regime. J. Med. Chem., 2023, 66, DOI

Vietor, J.; Gege, C.; Stiller, T.; Busch, R.; Schallmayer, E.; Kohlhof, H.; Höfner, G.; Pabel, J.; Marschner, J.; Merk, D. Development of a Potent Nurr1 Agonist Tool for In Vivo Applications. J. Med. Chem., 2023, 66, 6391–6402. DOI 

M. Komabayashi, T. Stiller, S. Jopp, J. Mol. Liq. 2021, 325, 115167. DOI