Tanja Stiller

Department für Pharmazie - Zentrum für Pharmaforschung - Ludwig-Maximilians-Universität München Butenandtstraße 7 D-81377 München Zi.Nr.: C1.053 Tel.: +49 (0)89 2180 77243 Fax.: +49 (0)89 2180 77247 Mail: Tanja.Stiller@cup.uni-muenchen.de

Research Interest

Nuclear receptors are a family of proteins that function as ligand-activated transcription factors and regulate gene expression in a ligand binding-dependent manner. I focus on a master regulator of neurogenesis, the Orphan Nuclear Receptor Tailless Homologue (TLX). Based on library projects, synthesis of new ligands and investigation of biological activity by in vitro methods, I am trying to find potent agonists for TLX.

Publications

Ballarotto, M.; Willems, S.; Stiller, T.; Nawa, F.; Marschner, J.; Grisoni, F.; Merk, D. De Novo Design of Nurr1 Agonists via Fragment-Augmented Generative Deep Learning in Low-Data Regime. J. Med. Chem., 2023, 66, DOI

Vietor, J.; Gege, C.; Stiller, T.; Busch, R.; Schallmayer, E.; Kohlhof, H.; Höfner, G.; Pabel, J.; Marschner, J.; Merk, D. Development of a Potent Nurr1 Agonist Tool for In Vivo Applications. J. Med. Chem., 2023, 66, 6391–6402. DOI 

M. Komabayashi, T. Stiller, S. Jopp, J. Mol. Liq. 2021, 325, 115167. DOI