Úrsula López

 

Research Interest

Deciphering how small molecules interact with nuclear receptors at the molecular level

Publications

Willems, S.; Busch, R.; Nawa, F.; Ballarotto, M.; Lillich, F.; Kasch, T.; López-García, Ú.; Marschner, J. A.; Rüger, L.; Renelt, B.; Ohrndorf, J.; Arifi, S.; Zaienne, D.; Proschak, E.; Pabel, J.; Merk, D. Structural Optimization of Oxaprozin for Selective Inverse Nurr1 Agonism. J. Med. Chem., 2024, 67, 13324–13348. DOI

Sai, M.; Vietor, J.; Kornmayer, M.; Egner, M.; López-García, U.; Höfner, G.; Pabel, J.; Marschner, J.; Wein, T.; Merk, D. Structure-Guided Design of Nurr1 Agonists Derived from the Natural Ligand Dihydroxyindole. J. Med. Chem., 2023, DOI 

Adouvi, G.; Isigkeit, L.; Lopez, Ú; Marschner, J.; Schubert-Zsilavecz, M.; Merk, D. Rational design of a new RXR agonist scaffold enabling single-subtype preference for RXRα, RXRβ and RXRγ. J. Med. Chem., 2023, 66, 333-344. DOI